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The presentation will be given by
“Stromal Cell-Hydrogel Construct Possibly Generates Clinically Relevant Neo-Tissue In Facial HIV-Lipoatrophy Phase 2 Pivotal Multicenter Clinical Trial: Early Analysis On Testing Patient Sample”.
Additionally, data from the laboratory of
“Three Dimensional Ultrasound For The Accurate Imaging And Quantification Of Adipose And Synthetic Tissue Grafts”.
About Facial Lipoatrophy
Facial wasting or facial lipoatrophy is the loss of subcutaneous fat from the face and is associated with medication for treatment of HIV infection. The longer a person is on HIV medications, the greater the likelihood of developing problems with facial wasting. Signs of lipoatrophy include the loss of subcutaneous fat primarily in the temporal region and cheeks and this tends to produce an emaciated appearance.
Renevia® is a medical device that was developed as a replacement for whole adipose tissue in cell assisted lipotransfer (CAL) procedures by recreating many aspects of the adipose tissue extracellular matrix. Renevia’s hydrogel polymer network provides the requisite amino acid sequences for adipose stromal vascular cell attachment and supports proliferation, localization, and adipogenic differentiation. Once implanted, Renevia provides a 3-dimensional matrix with pliability comparable to that of native adipose tissue, restoring texture in the short term while promoting soft tissue regeneration in the long term.
An important attribute of the Renevia hydrogel is its high water content, which is greater than 98 percent. As a result, the hydrogel is highly permeable to oxygen, nutrients and other water-soluble metabolites. Renevia mimics the extracellular matrix and the individual components of the hydrogel can be cross-linked in situ, thereby allowing the seeding of cells prior to injection in vivo without compromising either the cells or the recipient tissues.
In addition to the development of therapeutics, BioTime’s research and other activities have resulted, over time, in the creation of other subsidiaries that address other non-therapeutic market opportunities such as cancer diagnostics, drug development and cell research products, and mobile health software applications.
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