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The first of these new products is ReGlydeTM, a
cross-linked thiol-modified hyaluronan hydrogel for the management and
protection of tendon injuries following surgical repair of the digital
flexor or extensor tendons of the hand. The product is intended to be
applied in the vicinity of the repaired tendon via a syringe or similar
device immediately prior to closing of the surgical area. Separation of
the tendon from surrounding tissue has been shown to significantly
reduce post-surgical adhesions that can lead to complications such as
restricted finger mobility and flexibility.
The second new product, PremviaTM, is a HyStem® hydrogel formulation of cross-linked thiol-modified hyaluronan and thiol-modified gelatin for the management of wounds including partial and full-thickness wounds, ulcers, tunneled/undermined wounds, surgical wounds, and burns. Due to its high water content, PremviaTM is able to donate water molecules to the wound surface and to maintain a moist environment at the wound bed, which is critical for wound healing. Additionally, the biodegradable matrix provides a scaffold for the cellular infiltration and proliferation as well as capillary growth needed to promote healing. There is significant competition in the wound healing dressing space, however, one advantage that PremviaTM appears to have over most other technologies is the ability to flow into the wound and cross-link, or change from a flowing liquid to a semi-solid gel consistency, in-situ, thereby providing a moist environment to every part of a wound which a traditional covering cannot.
Both ReGlydeTM and PremviaTM are
expected to be regulated as medical devices in
PremviaTM is also intended to serve as a foundation for the further development of bioactive wound healing products that could deliver biological factors or cells to accelerate wound healing. PremviaTM may face a different level of regulatory approval for those uses.
Significant quantities of the components common to ReGlydeTM
and PremviaTM have been manufactured under cGMP
OncoCyte Corporationis developing products and technologies to diagnose and treat cancer.
ES Cell International Pte Ltd., a Singaporeprivate limited company, develops hES products for research use.
OrthoCyte Corporationis developing therapies to treat orthopedic disorders, diseases and injuries.
ReCyte Therapeutics, Inc.is developing therapies to treat a variety of blood and lymphatic vascular disorders, as well as products for research using iPS and other cell reprogramming technology.
Cell Cure Neurosciences Ltd.is an Israel-based biotechnology company focused on developing stem cell-based therapies for retinal and neurological degenerative diseases. Its lead product is OpRegen® for the treatment of macular degeneration.
LifeMap Sciences, Inc.markets, sells and distributes GeneCards®, the leading human gene database, the leading human gene database, as part of an integrated database suite that also includes the LifeMap Discovery™ database of embryonic development, stem cell research and regenerative medicine, and MalaCards, the human disease database. LifeMap Sciences also markets BioTimeresearch products and PanDaTox, an innovative, recently developed, searchable database that can aid in the discovery of new antibiotics and biotechnologically beneficial products.
Asterias Biotherapeutics, Inc.is a newly formed subsidiary whose first acquisition was the stem cell assets of Geron Corporation, including patents and other intellectual property, biological materials, reagents and equipment for the development of new therapeutic products for regenerative medicine.
Statements pertaining to future financial and/or operating results,
future growth in research, technology, clinical development, and
potential opportunities for
To receive ongoing